There's someone out there with a video where he ends up with a score that needs E72 Exponential Notation to show up (just for comparison, a Million Million is only E12).
How? By ending a run with 28 cards, which all of them are the king of hearts. Some of which have planet seals (which feeds his multiplier through a card that gives +0.1 multiplier per planet card you play) , some of which has retrigger seals.
This, combined with the plasma deck (which averages out chips and multiplier before doing score caluclation, which can make a difference, compare 100 x 1 vs 50.5 x 50.5)
Balatro Science: Introduction to Infinity (1.0.0h) - YouTube
https://www.youtube.com/watch?v=jEsegOW8MCY&t=0s