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We first knew that the mother was in the class that Ted accidentally started teaching in on his first day, he said so at the end of that episode I believe. Then when he met Rachel Bilson's character (the girl he dated), she said that she knew him because she was in that class. Then we found out that Ted was going ape shit over all the stuff he was finding in her apartment, only to find out that it was her roommate's...one of which was a smaller item that they flashed forward to being in the room behind the kids as they're being told the story.
I think that's pretty much the linkage. We don't know much about Barney's sister other than when his father mentioned that he had a daughter who was in college close by. Considering we met the son, but not the daughter, seems like they did that for a reason.
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