[Yoda]

In nickle and dime defenses 99.99% of the time there are no substitutions.

I have never seen a sub done (but that doesn't mean it can't happen). But I did a test a while ago in which I set the defense to 100% nickle and the only plays where someone not on the depth chart played was when the game forced the defense into Dime coverage.

So, if you have crap for back ups and absolutely need your base defense on the field 100% of the time, run all nickle/dime.