I'll +1 the Museum of Science and Industry. That one was my favorite growing up. The Art Museum and the aquarium are also great.
For food, love Giordanos and Garrett's if you like popcorn. I recommend the caramel/cheese mix.
Also, try Zed 451 (zed4521.com), a churrascaria on N. Clark that my best friend took me to when I was there a few years ago. Excellent food.
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