I have been messing around with the in/outs on the main page while leaving the CFM in outs at default and have been encouraged by what I am seeing so far. I haven't had time to test as thoroughly as I would like yet, but your post has reaffirmed what I am seeing to date.
I too have lowered the OL and QB to values similar to yours (along with CBs and S) and 65 fatigue and have not seen them leave the field (13 min qtrs, 14 sec run off). I am using 82/86 for the RBs. I am in pre-season though and have not been able to test a full (120-130 play) game with the starters as they come out after the first quarter. Soooooo....
Could you tell me what you're seeing with regard to the disappearing players glitch late in the game? This is one of my concerns with the 65 fatigue moving forward to the regular season.
I also wondered, with the 58/64 for running backs, are you getting the majority of the subbing late in the game, or spread throughout the game? Perhaps my 82/86 RB with the higher fatigue may catch up to me later in the games and cause the disappearing act. RB and DE/DT are where my in outs are highest in order to get a good rotation.
One final question, do you notice any higher injury frequency with the higher fatigue setting?
It adds a great dimension when these subs work properly. It forces you to carry good depth in your roster and not just for injury.
Thanks for sharing your findings!