Not impossible...
Been playing 2k for 11 years, I've Won a handful of games so far this year. Playing 10 min quarters.. This is my list of things that are crucial to winning on HOF Sim.
1. Play only on Ball D.
2. Get to free throw line as much as possible.
3. I only play with one team and have to do your best to learn everyones release as good as possible.
4. Call timeouts whenever you think the CPU is going on a cheese run.