Man, those YouTube comments are completely disgusting.
I feel bad for the people who work on these videos, only to have all that nonsense spewed underneath.
2K should consider upping their moderation or just disabling comments on these videos altogether.
Anyway, a 4-out 1-in offense based on pick and rolls is extremely difficult to stop in 2K15 if you have the right personnel (explosive point guard, hard-hitting, athletic screener, three shooters spotting up). The AI just doesn't react very well to ball screens, and they don't always make the appropriate decisions when helping out.
But I'm sure Visual Concepts already knows this and is working to improve the defensive logic for 2K16.