Just so we're clear and there's no confusion, I'm not necessarily "Simulating" seasons, I'm just going to be using the new Simulation Gameplay setting (they added Arcade, Simulation, and Competitive).
But to answer your question, I more than likely will not use players who are suspended until the week they are supposed to come back, I'm not sure yet because of course the cpu will still use their players who are supposed to be suspended so it may seem silly for me not to use them.. Not using Zeke is really gonna suck because he's really fun to use for me but in real life I think we'll be okay without him for the time being.