Yeah, I definitely feel your frustration there, like you say (without getting too spoilery) there are characters later in the game you are highly recommended to add, but if their skillsets overlap with what you've already got, it's kind of crappy.
I basically had to lose my only source of explosives and armor modding halfway through the game... which really sucks. And you can definitely get yourself down an alley where a quest you've spent 45 minutes getting to the end of isn't (and might not ever) be resolvable with the skills you have.
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