Mental health wise, I'm done with Covid. I'm fully vaccinated + booster and will continue to take whatever future booster is required, but I'm ready to travel again.
The concern has been what happens if I'm in country X and there is a lockdown and I cannot return to the US as scheduled. Or if I test positive just before my return to the US and I have to quarantine for 5-14 days.
All of that matters will matter less this year. Wife and I are still on track to retire sometime this year. Only thing that will cause us pause is if the stock market really, really tanks. Otherwise, going to find a highly vaccinated country, find the cheapest flight (even if there are 2+ stops, 30+ hours of travel etc.) & cheapest acceptable hotel, and go have fun.
Right now, the 4 destinations under consideration are Portugal, Spain, Italy, Phuket (sandbox program). They seem willing to take tourists. I would love to travel China, Vietnam, Japan but they are currently not welcoming tourists.
FWIW, here's a list of vaccination rates by country.
Coronavirus (COVID-19) Vaccinations - Our World in Data