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We had an older dog that went blind when I was a kid and got along just fine. IIRC the key was not rearranging any furniture so she knew the layout of the house.
As for doing what is best for the dog, I would listen to your vet, she is the expert. I think maybe the best course of action with your wife is let her know you will do all you can that is reasonable, but if the vet tells you it may be time you need to listen to the expert.
There are few things more selfish IMO than keeping a suffering pet alive for your own reasons. In your heart of hearts, or your wifes as the case may be, you will know when the time is right.
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