As far as injuries go, I'm finding that if I follow what I do in FOF it works pretty well. If a guy is injured and is probable after his injury, I play him. If he is hurt worse, I wait until he is completely healed (unless I'm absolutely desperate or it is the last game of the year.) So far, I haven't had any guys become reinjured or hurt worse doing this. However, I just lost my star RB to academic difficulties with several big conference games coming up
I had been managing academic issues well to this point, and he is my first guy to go onto probation in a season and a half.
Edit to add: Is it my imagination, or was offense toned down in the 1.02 patch? It seems that way in my current career, and I like it for the most part.