Just shut down all background programs, and turned off facegen.
Simmed from 08/01/2004 to 07/31/2005 in freaking 3 minutes and 11 seconds.
I have one league at each minor league level, and no college or high school leagues. Remember, this is a 16-team league, but still, that's approaching Mogul-esque speed.
When I really play OOTP, I tend to sim a month at a time, so I just timed one month. July 2006 took me 31.25 seconds.