B-17, Queen of the Skies is my favorite solo game - it's an old Avalon Hill game but you can find a copy on Ebay frequently, or you can play it on Vassal and find the rules online - you run a bomber trying to make it out alive through many missions.
Also, some other games that are made for multiple players play quite well as solo games - especially more abstract games - Ingenious and Tayu are ones I play solo occasionally.
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