Yeah, I agree with that. I've always found the running game in 2K5 and APF to be much more true-to-life than anything EA churns out. You really have to read your blocks and hit the holes when they open up. When you break a big run in 2K5 or APF, you feel a sense of accomplishment b/c you let your linemen do their job and found the opening to break off the run.
In Madden, it never felt realistic to me. You'd either rip off an 80-yard run, or get stuffed at the line. Linemen never really executed their blocks properly on sweeps or tosses, so the only way to find success with those runs was to hope you had a fast RB and jam down the speed burst to run past the D.