4-4 is great against flex bone, so is 4-2-5. Pinch the D line and widen the linebackers, the OLB's on both sides cover the outside threat while the ILB's and DT's cover the inside run. Also 1-5-5 prowl is good when you move all the players around, the qb doesn't know who to read on triple options, but it leaves you vulnerable to fb dives. Hope this helps
I run a 46 and just call a run d towards whatever way the rb motions sometimes they go the other way more often then not they go towards the motion side
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