I use SMU and there are certain teams that do that to me also. When they start doing that I go to the pistol formation to spread them out, then mix in runs and passes from the same formation. No play-action because you will get sacked. Mix up your runs and passes.
Also you can actually set up plays. For example, if you've been using a run to the left in a particular formation, the defense will start to jump that play. Later call a toss to the right side using the same formation and the defense will jump the run to the left, giving you a big gain with the toss play to the right.