I've had this argument elsewhere, but that is blasphemy. Man coverage in this game is about taking away angles and getting user picks.
Taking away slants is simply a matter of cutting off the slant angles and once you figure out your opponent's primary read, you have all of the information you need to figure out their whole gameplan.
1. Find primary read.
2. Shift defensive line in direction of primary read.
3. Control available zone defender and cut off angle from QB to primary read.
You'll give up a completion to another WR against most good players on that play, but you will have found their secondary read and now you can call a play to have max CPU coverage in that area while you focus on stopping the primary read.
I've yet to see a person who has a consistent third option on plays once the first two have broken down, so you're free to roam with your user controlled player and pretty much play the QB and find where you think they will throw the ball. It's all stick skills from there. If they can still complete the pass, then you tip the cap to them for a job well done and dare them to do it again.