manual controls are the way to go man by far, and there are many other slider changes that can improve the game. I will say for the sake of passing right now, increase the passing speed to 55 for the user, and 60 for the cpu (so they won't be giving the ball away so often).
I also increase the passing inaccuracy slightly, I can't remember the exact slider this second though. I'll be back with more information, I didn't know anyone was even considering to play with fully manual controls, so I never bothered sharing my information.
while you wait, perhaps you can check out a recent ea sports video of mine, it's not impossible to play but it's very much a challenge. What I do suggest to those playing manual controls is be a lot more judicious with your choices in the game or you will draw a lot of bad turnovers. You'll love when you get the hang of it, also utilize the training, that will get you ready quicker, it will always be a challenge though, that's why I said make even better decisions on the game if you use these controls
anyhow, I have much better video than this that I can share but here's a glance at gameplay on manual:
http://www.easports.com/media/play/video/157029073
http://www.easports.com/media/play/video/157028909 - closer view