It's still tough... this is concerning two factors:
- Trust
- Cooperation
Granted, they are both intangibles, but you need to make sure that your QB is trustworthy as to who to pass to and what plays to call, or your WR to attempt to catch the ball. Likewise, you need your defense to be able to cooperate with their zone, their position, and their responsibility. You don't cover a player you're not supposed to, you don't blitz when you're not supposed to, etc.
It's tough... it's a stretch... but it could work. I wouldn't buy a PC football game, though.