Since NFL 2K5 was released, the Bills, Cardinals, Chargers, 49ers, Jaguars, Lions, Panthers, Seahawks, and Vikings have all redesigned new jerseys, and the NFL changed its uniform manufacturer from Reebok to Nike. It is literally impossible for you to make a case for this on that account. Not to mention the Cardinals, Colts, Cowboys, Giants, and Jets all now play in new stadiums and countless other playing venues have been renamed.
I'm surprised Ronnie would tweet something just to rile up the 2K fan base so irresponsibly. Absent a break in the exclusivity agreement which I don't foresee, NFL 2K is not coming back, and the team that last worked on All Pro Football 2K8 has long since dispersed on that account.
All that said, I would welcome the return of NFL 2K; however, I peg the odds of such happening at 0%.
NINJA EDIT: Doesn't appear Ronnie actually tweeted this and this is just another wishful thinking thread, I misunderstood.