As an Eagles gamer, try this:
Run straight at him. Look at where his LBs are and go straight at him. A lot of times, people who just use the DE can't tackle the runner, so you may be able to get past him for a few yards. Three step drops might work, and use the FB as a hot blocker to slow him up. Really, the Eagles' DBs got hosed in the game, as they're just not that good. SO it's possible to get past them.
Try also running screen plays. Draw him in, and WAP!
On defense, what I do with guys who like running is this: They perfer running to a side, so I try to take my DE and use him to shadow that side of the line. I'll stack the other side to push him over to me. Also, try zones with delayed blitzes. They work as well. Finally, blitz him from all different sorts of angles - you'll accomplish two things:
1) You'll put pressure on him to make a mistake, where your guys can take advantage, and
2) You'll get him thinking, instead of normally reacting. This is where more people with no skills screw up.
Keep at it, and you'll do fine.