Here is my current set up and the game runs buttery smooth. No micro-stuttering! I turned Antialiasing off and let the GPU do the work and that seems to have been the best outcome. DSR factors are used only because I record at 2560x1440 and only have a 1080p monitor.
Here is a sample of what mine looks like now. Remember that it is YT and they knock down the video quality by leaps and bounds.
Video
Global Settings
DSR - Factors 1.78x
DSR - Smoothness 33%
Power Management Prefer maximum performance
Everything else on default from factory
Program Settings
Image Sharping Sharpen 0.50, ignore film grain 0.17
Ambient Occlusion NA (Greyed out)
Anisotopic filtering Application-Controlled
Antialiasing-FXAA ON
Antialiasing-Gamma Correction ON
Antialiasing-Mode Override any application setting
Antialiasing-Setting 8x
Antialiasing-Transparency 8x (supersample)
CUDA-GPUs Use global setting (All)
Low Latency Mode ON
Multi-Frame Sampled AA (MFAA) Use global setting (Off)
OpenGL rendering GPU Use global setting (Auto-select)
Power Management Mode Use global setting (Prefer maximum performance)
Shader Cashe Use global setting (On)
Texture filtering-Anisotropic sample optimization OFF
Texture filtering-Nagative LOD Bias Allow
Texture filtering-Quality High Quality
Texture filtering-Trilinear optimization ON
Threaded optimization ON
Triple Buffering ON
Verticle sync ON
Virtual Reality pre-rencered frames Use global setting (1)
Change Resolution tab
ultra HD, HD, SD
1080p, 1920x1080 (native)
use Nvidia color settings
Adjust Desktop Color Settings tab
use Nvidia settings
change contrast to 52%
change digital vibrance to 60%
Game Graphics settings
Fullscreen Resolution 2560x1440
Window Mode Fullscreen
Antialiasing Off
Frame Rate Lock to 60fps
High Dynamic Range (HDR) Off
VSYNC On
Triple Buffering On
DirectX version 11.0
Rendering Quality Custom
3D Grass Auto
Bloom Auto
SSAO Auto
Depth Fog Auto
Lens Flare Auto
High Res Circular DOF Off
Mesh Quality Medium
Shadow Quality Medium
Crowd Quality Low