Here my sliders set; if anyone wants to give it a try
Settings CFM
Instant Starter - Off
Salary Cap - On
Skill Level - All-Madden
Quarter Length - 12 Minutes
Accelerated Clock - On
Minimum Play Clock - 20
Game Speed - Fast
Player Progression Frequency - End of the season
Coach Firing - On
Game Play Tuning - Yes
Injury - On
Pre Existing Injury - On
Trade Deadline - On
trade Type - Enable All
Relocation Settings - Disbabled
League Type - All
Team Settings
Play Call Style - Enhanced
Coin Toss 1st Choice - user choice
Coin Toss 2nd Choice - user choice
Strafe Assist - Off
Pre Snap Menu - On
Coaching Tips - Off
Player Names - Pre Snap
Heat Seeker - Off
Ball Hawk - Off
Switch Assist - Off
Camera Settings - Standard
Defensive Graphics - None
Kick Aiming Arc - Off
Previous Play Information - On
Play Call Button Layout - Y,X,A
Camera Toggle - On
Tutorial Popups - Off
CPU Settings
Fill Roster - Off
Re-Sign Players - Off
Progress Players - Off
Sign Off-Season Free Agents - Off
Simulate Game Prep Activities - Off
Game Options
Injuries - 56
fatigue - 65
Min Player Speed Threshold - 19 (suggestion of JoshC1977; great way to slow down the pass rushers)