I was JUST going to post about this the other day, you literally spoke on EXACTLY what I feel is an unbelievably overlooked issue in Madden gameplay wise. Proper implementation of fatigue would effect SO much in a game to game basis. Just think of how you could base your attack just off of that. A "Ground and Pound" offense that wears on a defense over the course of a game. The Patriots exhausting spread passing attack from a few years back. Even the ill-fated Chip Kelly breakneck speed hurry-up style of a few years ago. I mean seriously, gameplans have successfuly (and unsuccessfully) been built around the philosophy of simply breaking an opponent down when team talent and versatility were not an option.
This is terribly non-existent in Madden currently, which is even more puzzling considering that I did exactly what was described above, back Madden 12! I play currently on 10:00 minute quarters on Madden 18, with fatigue at 55-60 now and have occasionally had drives that last nearly if not an entire quarter, looking to destroy defenses with T.O.P alone, just for them to come out the next drive fresh as daisies..not fun. And not that I want to go back to Madden 12 solely for that but still. It would put much more value on team depth and personnel rotations. And I couldn't agree with the original post any more.