I don’t know if I have the best answer, but this is what I do:
1) If I’m running nickel I user the nickel CB. It sounds hard but it’s really not. Bump and run coverage is my absolute go to. I use a big nickel corner with high press ratings. I traded 2 firsts and a 5th for Jamal Adams and run a big nickel with him quite often.
2) if your DBs are lined up 7-9 yards off the line of scrimmage you’re already screwed, it simply doesn’t work in this game. Bring them in. I press coverage almost everything because I have 2 elite press corners on the outside.
3) shade inside. I even see my corners get underneath slant routes in man coverage doing this. In this game I’d happily give up outside leverage for the exact reasons in your OP.
4) if i deploy just 2 CBs on whatever play I call I always user the lesser rated one. Once again, sounds hard but it’s not. Just zoom out of your defensive cam so you can see who you’re controlling. Using strafe (L2) to peddle back really helps get into good position.
Hope this helps even just a little bit. Sadly madden user AI can’t cover the middle by itself so you have to improvise. Super frustrating.
Only issue with this is if you have average CB, you’re going to get beat deep every time. Non-controlled CBs bite so easily on play action.