I've given up in search of the unicorn slider setting. Each year I get the game and each year I think the game would be 'perfect' if I could just find that perfect setting... it does not exist.
So what I do is play on All Pro. All Madden is out of my league. I also created 10 somewhat random Human sliders and 10 somewhat random AI sliders and before each game, pick one. My logic is that if I have, say HUM passing set to 80, then every single game, the QB will pretty much have laser accuracy. So the reason I randomize my sliders is so that each game feels different.
Just my opinion.
This is an interesting approach actually. I might try that.