So an important thing to remember is that the NFL is a passing league and you can't just take away
all intermediate passing. There are too many horizontal stretch concepts which conflict underneath zone defenders, and (in Madden at least) an average receiver generally beats an average cornerback in man coverage.
There are some things you can do, though:
- Stick with your gameplan plays. You only the the player ratings boosts provided by your gameplan when calling those plays.
- Know what your opponent is trying to do and call counters to take that away. Cover 4 Quarters can take away the Smash concept, for example; the play-side deep quarter players will double the slot corner route, and the quarter flat defender will sink to the curl / hitch. In Franchise, you are provided a breakdown each week of your opponent's favorite concepts so you may gameplan more strategically. You don't get this data in other modes, which is unfortunate, but you can pick up tendencies as a game goes on.
- Know your opponent's personnel and change your play calls accordingly. For example, the Saints only have one wide receiver with 90+ SPD, Deontay Harris. Cornerbacks are generally faster than receivers in Madden 22. As long as you keep your fastest CB matched up on Harris, you can probably get away with calling a fair amount of press Cover 1 variants, press Cover 3 variants, and zone blitzes. Dare the Saints to try to beat you over the top with their personnel that will struggle to do so. Do watch out for Alvin Kamara working against linebackers underneath when you blitz, though; he's got the Backfield Mismatch ability which basically guarantees he'll get open in man coverage against any linebacker.
- Rotate your defensive linemen. Your DLs can't use pass rush moves or shed run blocks (assuming they don't have the Run Stopper ability) once they run out of rush move points. Players generally recover one rush move point at the end of every play, but might use multiple in a play, so they will run out. Rotate guys in regularly
before they get fatigued so you always have a chance to stop the run and/or pressure the quarterback.
- Know which calls you are comfortable with against trips sets. Passing out of trips formations is very common in the NFL nowadays. Unfortunately Madden doesn't offer many good options for defending trips. Cover 4 Quarters / Cover 4 Palms / Cover 6 have built-in trips checks. Depending on the play call, I find that Cover 3 Cloud / Cover 3 Buzz can also be useful. Figure out what plays you want to use to defend trips and really focus on knowing your assignments in those calls.
- Understand that each coverage you call gives up
something/. There is no coverage that takes away everything or is entirely foolproof, otherwise every NFL team would just run that defense. Understand where you are vulnerable in each coverage when you call it so you can control your user defender appropriately.
- Find a base defensive play call you are comfortable with and just get that down-pat. For a lot of teams, this is Cover 3. For some teams, it's Quarters. A few still base out of aggressive press-man. Point is, find one base call you like, know how that works like the back of your hand, and build off that.
- I said this before but I'll say it again to reiterate: mix up your play calls. It's my strong impression that the CPU aggressively picks up on repeat play calls this year.