I play with the Bills about 85% of the time, and they're not as terrible in-game as people make them out to be. Just a few reminders, though:
-Lindell and Moorman are among the best kickers in the game, providing the user is kicking right. If Lindell can (just barely) kick a 55 yarder in Madden and has the potential to on every field goal, that's a good thing.
-Kick returning. It's been a true asset for the Bills the past few seasons and it's the same way in-game. I've returned about two punts and one kickoff with Roscoe Parrish alone, who's pretty dangerous if you are able to find the right lane. McGee (strangely) isn't as dangerous as Roscoe is, though. Why? I'm really not sure. I think his speed rating is lower than Parrish.
-Lee Evans is extremely dangerous, moreso than any Bills receiver. I can always find him in the open field and is a real asset when you have a defensive mismatch.
-The line isn't as strong as the players in it. I found I've been scrambling out of a non-existent pocket many times, which isn't fun...which brings me to...
-J.P. Losman. He can scramble well and throw with some power in Madden but there's really nothing special about him in comparison to other well-known starters.
-Lynch isn't too special running the ball with default rosters, I find I'm moving the ball much better with Anthony Thomas. However, I've been using the "train player" feature on him with elusiveness and speed in my Franchise, and he's become a real threat and gains much more per carry than his default self.
As always, your results may vary.