That isn't an issue limited to Madden 10. That is a Madden staple from the first Genesis Madden till now.
There are only 2 Madden games and one NCAA game where you could consistently throw over a defenders head and not worry about the defender swatting from 5, sometimes 10yds behind the play. That's NCAA 06, Madden 99, and Madden 07.
Play bump and run without 2 Deep Safeties on those games and it will be a long day for you.
On any other Madden game it is not uncommon to see a LB intercept a pass while he is 5yds from the line of scrimmage that is intended for a receiver running a post 30yds up field. I've even seen on Madden 08, which was the worst offender of this to me, a time where I was playing a friend and I lobbed a pass, while holding the joystick up to lead a receiver on a Go, while he was a good 15yds up field, and had a LB that was in a hook zone about 7yds up field, jump and intercept a pass that was probably headed at least 40yds up field. I put the controller down and we both traded in what is in my opinion the worst Football game ever made lol. This is not an exaggeration. I swear this happened.
Now I don't know what Valdarez is talking about specifically because I don't have NCAA and I don't think I have ever tried a middle screen. There is a reason for that. I know Madden.
You said that maybe he is trying something that works in another game and maybe that's why he is having trouble. That's probably the case. I have a great passing game in Madden, but not because Madden has a great passing game, but because I know what you can and can't do in the game. I learned a long time ago that real life passing strategies don't work in Madden. People that would be wide open in real life are covered in Madden because you can defend from so far behind the play. If a WR has a step on a DB IRL, that receiver is open. In Madden they need to have a good 10yds to be open or you will still probably be able to swat. People talk about how hard it is to play D on Madden and how the Offense gets upgrade every year and has an advantage. I don't know about that. I've seen many people online play Goal Line D the entire game with Bump and Run and have success. Why? Because in Madden you are pretty much never scared of someone going over the top. I know I dare people to pass deep by using BNR and Man and get burnt every once in a blue moon. No team IRL would put both DBs on an Island for a whole game, but in Madden, it's not a scary proposition at all.
Part of this, a big part of this, as Valdarez says, is because of trajectory. It's not the only issue though. No Route Based Passing is another. Not being able to throw to the spot on the field of your choosing, but instead, having passes tethered to receivers is yet another.
In short, Madden's passing game has serious issues. That doesn't mean that I can't pass, but it means that to a certain extent I have to use Madden strategy, because real life strategy doesn't work, and I hate that. So when you said that he is trying to do something that works in another game and applying to Madden, without success, you are probably right, Madden doesn't do passing like other games, which in this case is a bad thing. Most importantly it doesn't do passing like THE most important game. The NFL. And that is a big problem to me, regardless of whether I can still be successful passing, the way it is now.