The problem with Samuel and DRC is that both of these CBs are not physical. They have low press coverage, low block shedding, and low tackle ratings. I prefer to use players like Cortland Finnegan and Vonte Davis with Kyle Wilson as my nickle back when I draft. All three of these payrs have 90+ press coverage, have high block shedding and high tackle for a CB. Vonte Davis and Kyle Wilson have high man coverage ratings for a rookie and 1 year pro as well. Jarome Murphy [70 OVR] is a great 4th string dime package CB to add to your team as well.
In answer to your question, I want a run heavy team with a dominating physical 3-4 defense. I like to look for Vernon Davis with my 1st selection, Cortland Finnegan with my 2ed, and Calvin Johnson Jr. with my 3rd. Having Davis and Johnson as run blockers on the strong side and the passing threat they provide, you can really open up your offense with out having to invest too much into it. there are a lot of good defensive palyers who have lower OVR ratings you can take advantage of. if you paly the 3-4, look at Ravens backup DT 72 OVR T. Cody. He has around 89+ tackle, power moves, and block shedding as a rookie. His weaknesses are his lack of speed and his pursuit/play recognition. When looking for a NT in Madden, who cares? The NT isn't asked to chase backs from sideline to sideline or sniff out play action or rush the passer from the edge. A NT needs to plug running lanes and occupy blockers in the passing game. Having 90 or so tackle helps as well. What good is player who cannot tackle? Also look for 49ers LE Issac Sopoaga [71 OVR.] His wekaness is his 74-ish power moves in the pass rushing department. He has 94 or so block shedding and tackle. he is all about being a run stuffing DE. Not having to draft DEs, or a DT early allows you to pick LBs and offensive linemen in picks 4-9.