Until Madden allows these types of throws, the best passing options are almost always over the middle - be it slant, post, drag or in routes. I've never had much success with outside passes in Madden, unless the defenders completely blew their coverage. They've always been able to cover too much ground too quickly and jump too high in the air.
Actually I have no problems throwing the curl or comeback routes in Ncaa and madden. In fact sometimes I feel like it's cheesing. With that said you can see that they are trying to cut down the over the middle seam, post and mesh routes with the zone defense. The force over the middle pass in these videos ended in alot of ints.