This problem is so bad that it makes the game virtually unplayable for me, I'm strongly considering returning or selling it even though I'll only get a fraction of my money back. It's ridiculous. The game does a number of things very well, but there's literally no pass coverage whatsoever for the player's team.
I've tried every slider configuration I could think of, every play calling/pre-snap adjustment strategy, etc. and only one of two things ever happens. Either the QB completely destroys my defense (I've had several 2nd and 3rd stringers end up something like 40-42 for 450 yards and 4 TDs, the only incompletions being user picks), or I completely shut down the offense because I send heavy pressure and get 10-15 sacks per game. Neither of those is even remotely realistic.
The final scores actually tend to be pretty reasonable, I've been on both the winning and losing side of games that were 28-21, 31-30, etc. That's great. But the gameplay itself is so broken it's not even funny.
On sliders, put User reaction time on 93, and interceptions at 65. Put CPU pass accuracy at 13. The robo-QB's will starts missing throws but will still complete 50-70%. That you can live with. When Logan Thomas (57 overall) goes 26-26 for 400 yards against my D, you can surmise that the game is garbage out of the box.
On a related note I recommend hiking User run blocking to 65-75. If you dont your guys wont get any kind of a push like real life. It doesn't help that the CPU knows your plays before you start. It rips the psychology right out of the game. Huge difference between playing football and playing madden.