Yes.
Timing: You have control over swing timing but not over the PCI which is roughly "where the player was looking to hit" but NOT "this is where the bat is" (i.e. it's not a bat cursor like in PYS).
Zone: You control the PCI as well, so you have more certainty of contact/solid contact. That said, you also have to be able to either anticipate pitches or have an approach you can stick to.
Zone can tend to less K's and more consistency because of the PCI control. Timing - who knows what you'll get in regards to that (it's literally random with Contact slider, difficulty level, pitcher and hitter ratings all factoring in along with your timing as a user), which can cause bad (or no) contact in and of itself.
It's probably easier in Zone but it still can be difficult. It CAN be done, though, even in Timing.
You can do it - but the game might "penalize" it. You may see a lot of "Pulled Off" on your swing analysis, even if the PCI squares it up, because of your early timing. Might see "Weak" a lot as well. This is especially true if you use the Power swing (shrinks PCI and probably probably alters the chances of Weak/Solid/Normal, etc contact.
That said, if you do have a power guy and he gets "Solid" contact on a pitch like that and you have a pull swing, it is not impossible to get a shot to the gaps or over the fence.