Personally I find offense in 2k more engaging when it's built around passing and motion (more satisfying and puzzle-like), rather than right-stick combos / iso stuff (which feels Street Fighter combo-ish / Mortal Kombat Fatality-ish to me, and that was never my jam as a kid with video games), so I've never really developed the latter skills and can sympathize with you.
If you're trying to ease into the game without feeling overwhelmed, it can be helpful to start off with some 'money plays' that you can spam until you start to feel more comfortable breaking out of that box. I play as the Warriors, so I'm most familiar with their plays (though any team can use any play, so these aren't limited to the Warriors), but a few money plays I fall back on when I'm desperate for a bucket are (and you can add these to your playbook and set them in your Quick Plays):
- Quick 32 Horns: You bring the ball up, pass it to your center at the elbow, then just hold it until the play's designated shooter comes sprinting out from the left corner off screens, usually open enough to nail the 3 if he's a decent shooter.
- Give Warriors Fist 2: Similar setup as Quick 32 Horns, in that you bring it up, pass to your center at the elbow, then whoever brought the ball up cuts to the basket and very often it's an easy layup.
- Punch 3 Hammer: You bring it up, pass to the guy posting up, then almost immediately kick it to the weakside corner for a 3.
- Iso 13: Similar setup to Punch 3 Hammer, in that you bring it up and pass it to the post, except this time just wait till you have a shooter standing there at the 3 past the key, then pass it to him and shoot immediately. If he's a good, quick catch-and-shooter, you'll nail it a lot of the time.
- Fist 12 Quick: Literally you just bring the ball up then wait for a 3-pt. shooter to come curling out to you from off a screen, then you pass and shoot.
YMMV with those, as I often find money plays in YouTube videos not nearly as effective for me, so I think it's a lot of personal preference, but Practice Plays mode is a good place to workshop and find stuff you like. One thing though is that you should get comfortable with Icon Passing, because if you're not relying on dribble moves and stuff to get yourself open, you need to at least be able to hit an open shooter / cutter right when you see the opening, or not accidentally pass to the wrong guy.
As for iso-type moves, it's good to have one or two easy things you can use in a pinch. Really all I do on that front is sprint into a hard crossover (by tapping the right stick in the opposite direction) then shoot if it worked to generate space, or I just double-tap the shoot button to do a turnaround jumper, when I feel like the animation will move me in the opposite direction of where the defender's momentum is taking him. The latter you just have to develop a feel for over time.