After trying numerous sliders and theories, I think I have found something that is going to work for me. My old set became too easy and I couldn't the CPU to much at all on offense.
Going on Versuz theory that all sliders must equal 100 except for ST, I tried his theory out. Part of it was also that all sliders must be the same. I.E. if CPU Pass Accuracy was 35 then all the other CPU sliders had to be 35 as well. This worked to some degree but there were still parts of the game that I didn't like. So I decided to stick with the all sliders must equal 100 theory but tweak up or down on each slider as I needed for my paticular style. Here is what I have come up with. If you are struggling with finding a set that works for you, I recommend giving these a shot.
Tuner - On
Quarter Length - 9 Min
Game Speed - Very Slow
Threshold - 70
Penalties
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Offsides - 90
False Start - 60
Holding - 53
Facemask - 57
Offensive Pass Interference - 100
Defensive Pass Interference - 100
KR/
PR Interference - 50
Clipping - 60
Intentional Grounding - 100
Roughing the Passer - 53
Roughing the Kicker - 53
Sliders Hum/CPU
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QB Accuracy - 35/65
Pass Blocking - 35/65
WR Catching - 45/55
RB Ability - 35/65
Run Block - 35/65
Pass Coverage - 30/70
Pass Rush - 30/70
Interceptions - 35/65
Rush Defense - 30/70
Tackling - 30/70
FG Power - 50/50
FG Accuracy - 50/50
Punt Power - 50/50
Punt Accuracy - 50/50
Kickoff Power - 40/40