I'm going to use this thread to give some feedback.
I'll probably add to it over time, the more I play the game.
To start off with:
Quicker input for defensive hot routes
It's too slow to input defensive hot routes. Having to choose the individual player takes too much time. I suggest an icon based system, where icons appear over the players' head after you choose one of the currently available three options (Line, LBs, or DBs). From there you could quickly choose a guy and give him a hot route. This is much needed to make it easier to put individual players into press coverage, etc.
Quicker input for offensive position subs
As it is now you have to scroll through each offensive sub option with the right stick, and it's way too slow. I suggest a menu that pops up when you use the right stick, and then a button for each option (example: A=HB spell, B=Wide out swap, etc.). This would make formation subs a lot easier and quicker... Just a quick flick of the right stick, and then you choose your sub option.
Better notification of injuries
Too often in NCAA 11 I'll have a guy get injured and not know he's injured until I notice the sub during the next play, or when that menu pops up asking if I want to play or rest the injured player. There really needs to be an instant notification of when a guy gets injured, like a red flashing indicator at the bottom of the screen, so that you can adjust accordingly. Too many times I've had a RB go down, but not know it until I'm lined up and ready to take the snap for a running play. If I'm thin at RB then I'm kinda screwed, and really should know beforehand so I can call a play appropriate to the guys I have on the field.
Better end of the game highlight show
Axe the entire thing that currently exists... The play of the game and the snap shots... Those are really awful. I suggest you let users create their own custom highlight show, and it could be easily done (marketing departement, I just gave you guys a bullet point). Since all the highlights are currently given a letter grade, allow the user to set up filters... For example: Replay only the plays rated over a B- for the home team, and B+ for the away team... And then allow the user to set the camera angle: set to view from just one angle, or to cycle through different angles at random... Or something to that effect. You can kind of do that already, by just scrolling through the highlights by hand and doing it yourself, but this would be a better option than what currently exists (plus, yes, it'd give you another bullet point to market).