I had the same thing happen last night. it did it to me in the 4th quarter xbox360 started ticking then the game froze and I got the problem reading disk message. I wiped down the disk and rebooted the game. This morning I played 2 quarters of a game this morning before I went to work. Wish I would have had time to get thru the game.
Add me to the list. Bailed me out of a 23-7 drubbing @ home against the Cocks, though.
Is it possible there's something wrong with the drive? Overheating issues with the console, maybe?