Is this against the CPU or USER?
Against the CPU, there is not reason to play anything accepts press man coverage. The CPU never goes deep so cover 1 press is the only defense you need.
Against a USER, you have to defened the user's tendencies. I usualy conceed the first drive to scout the user. Man press works but you can easily give up the big play deep. Switch it up and bait the user into a false sense of security. I often times give the user the flats as a hot read. Then, when the time is right and the pressure is on, I give the same look but go cover 2 zone. If the user is lazy with his read, I can force a mistake, and maybe get a pick 6.
The CPU is predictable and boring. Against Users, you have to play against the brain of the user. If the user is good, then you may never get a stop. Then the game comes down to clock management and trying to have the ball last with a chance to win!