On anything less than Heisman I would put human defensive awareness at 0, human break block at 0, cpu run block at 100 and cpu RBA at 70. It was rare to see a 100 yard rusher against me in even matchups or where the cpu was the better team. On Heisman I would use the same settings except I had human def. awareness around 70. I know that probably hurt the running game but I did it to help stop the cpu QB from completing a ton of passes.
If I drop human break block to 0 and increase cpu run block to 100, their OL should be man handling me and they never did on any level. The fact I never saw it on Heisman was dumbfounding this year. The only real way to boost the cpu running attack was boosting the cpu RBA which would allow them to break a long run every once in awhile but I just never saw the methodical rushing attack stuff it down my throat. I've always been able to fix this in the past as the default cpu rushing attack is usually horrible but the weak sliders this year made that virtually impossible. I do play as a LB against the cpu.