I have played 2 season now without the patches but keep the tuners. I can tell you it does help out big time. Other areas have opened up as well. I can now return kicks and the high jump gold medalist who play linebacker on this game are tuned way down. I don't think 20+ games is a placebo effect.
If you enjoy the game with all the patches then this is not for you. If you play online play this is not for you since you have to have the patches for online play. I only play offline, human vs cpu dynasty mode. Some of the glitches like the backward pump fake are not a issue since I don't do it and the cpu never would in the first place. I have only seen the missed filed goal and the kicking team get the ball back once, I was up by 40 and it was the 4th qtr.
For me the game was in my car waiting for me to swing by a Game Stop to trade it in. I had not played it since the last week in September. Something I have never done before. I have bought this game every year since 1998. I only play this game, Madden, and Choops2k8. Since removing the patches I have fallen in love with this game again. I have had a few people PM me about this as well who have found new love for the game. You can always try it and if you don't like then download them again. Just know that when you remove the NCAA 11 patch you remove all patches for all games. It took me less then 10 minutes to redownload all the patches for the other games I play.