In my dynasty, Western Kentucky upset Alabama 20-17. It was so unbelievably unrealistic that I quit my game I was playing, exited out of dynasty and re-loaded from my previous save (autosave was off). Every time I simulated the WKU-Alabama game though, the result was the same. It seems that perhaps scores are already pre-determined once you start a dynasty. The only way I could fix this was to play the game myself as Alabama and make sure I beat WKU.
Now, I'm not a 'Bama fan at all. I'm playing as SJSU in my dynasty. But the result of WKU beating The Tide in Alabama was so ridiculous and improbable that I had to do something about it.