If you want a "combo" feeling between the two of them run the 4-3 Under as your base defense. The alignment is basically that of a 3-4 except that the WDE in the 4-3 has his hand in the dirt instead of standing up like in a 3-4. Also brings the SLB closer to the line of scrimmage and can look like a 5-2. This is the base defense I operate out of.
Really though the difference between the two is about gap control but I don't think the game gives the flexibility for defensive linemen to differentiate in that way right now.
Edit: if you really want to get technical and understand what I mean about gap control read this:
http://www.grantland.com/story/_/id/...triots-defense
Edit #2: mind you in the 4-3 Under in game, the DT who lines up opposite the center (the nose tackle) is actually the second DT on the depth chart so you may have to re-order it for it to make sense on the field even though on the depth chart it would seem weird because the game doesn't split up DT and NT.