Ah, for the first time I can contribute something. When you Quicksave you can choose Career, Profile or All. I ran a simple test and my settings did survive exiting and reentering the game after being saved via Quicksave.
BTW, I tried your sliders to beef up running and tone down passing. the ones where the Offense positions were 40, 40, 40, 80, 60. Unfortunately the next opponent for my fledgling Dolphins was San Diego. LT racked up 295 yards rushing, 1 yard short of the NFL record! Probably not a fair test (Ronnie Brown didn't have an exceptional game).