The primary motivation for this thread is the "Double Me" zone ability possessed by some wide receivers such as JuJu Smith-Schuster (who torched me in the M20 beta), A.J. Green, and Mike Evans. As a refresher, the Double Me zone ability gives an in-the-zone receiver a significant advantage in aggressive catch scenarios when single-covered.
I fear a lot of people are going to initially react to this ability with "OMG it's OP!!!" once they end up on the wrong end of it, particularly with (in my personal experience) the ubiquity of Cover 3 Match in user defensive schemes in Madden. Simply matching the deep third CB into man coverage (or even the outside quarter CB in Cover 4 Quarters) onto the #1 outside receiver won't work to counter a Double Me receiver who's in the zone, unless maybe you have your own in-the-zone CB over there, because you'll almost always get single coverage on that receiver based solely on the play call.
As a counter, I'd initially look into defenses with a deep half safety - Cover 2 Carry and 2 Man Under come to mind. Obviously those leave you very vulnerable in run defense because you take the eighth man out of the box, and obviously have their own pass defense strengths and weaknesses. I also see myself calling Cover 6 more (it's something I rarely used in past Madden games as I never understood how or when to use it) as to offer defense against unbalanced passing sets, particularly when it's the Double Me receiver who is isolated on the weak side. By default, Madden orients the Cover 4 side of the Cover 6 defense to the passing strength of the formation, so the aforementioned isolated X-Factor receiver will be bracketed by the cloud flat CB (who should carry the vertical route of the #1 WR) and the deep half safety, and the other half of your defense can still man-match and have some semblance of run defense.
Tell me if I'm wrong on any of this also in addition to providing your own strategies and tips, obviously.

Absolutely guaranteed to work. 
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