i totally agree on the importance of the fatigue slider. it's really is useless to list the settings for the other sliders and talk about how your games are playing without talking about fatigue.
setting computer running at 40 with a computer fatigue of 30 is a completely different animal that computer running at 40 with a computer fatigure of 8. fatigue also affects your passing accuracy and the number of drops you'll see by your wr's. it really is a 'global' setting.