Haha, that's hilariously wrong. In real life, nobody plays man to man against teams like Texas Tech all game, because you're just asking to get raped on crossing routes, and their 4th WR is probably better than your 4th CB.
Most people defend the spread in real life by playing zone coverage and forcing the offense to work their way down the field. The problem is that on the game, every QB is ridiculously accurate and WRs never drop passes, plus your front 4 gets almost no pressure, so even mediocre offenses can do just that everytime out.
I can tell you that OU probably plays man to man defense less than 1/3 of the time, particularly in conference play when we face spread offenses.