thats strange
did you examine the disk?
I would say what about disk speed, but if NBA 2k works fine then this game should work well also.
I say delete the patch and the game, all the files and folders and reinstall again.
makes sure there arent any files left behind anywhere.
it could be that the graphics card is not compatible with the game. with your new video card do you have the latest drivers. if not, go to the manufacturers website and download the latest/newest drivers for your video card. see if that works?