1. For my Lab testing I use the Werewolfs to play against since that team is set up like most online teams.
2. If you know he is using arrow routes, drag routes or inside routes with his WR than shade your CB's inside. Hot route your Safeties to cover the deep sidelines incase he decides to go deep on you. If he will go to a quick out than your best bet is to manually cover that with the LB closest to the WR your worried about because out routes are very hard for the AI to do right.
3. The best defense for a sure run up the gut is the Bear defense. Do the Inside stunt and the play that has the Safety and the LB blitzing right up the middle.
If you don't want to go that route I would suggest this. I will do this to anyone who plays like he does.
I would hot zone my OLB's from the 4-3 defense to both flats and put my CB's in a low zone like the 2 hard. If you have both of your OLB's hot zoned to the flats they will go there if he passes and if he runs they will react to it normally. I would manually bring down the safety that does not help cover his biggest threat ( Meaning don't take the safety that is over the top of Jerry Rice, Take the Safety who is over the top of a lesser WR ) right over center and as soon as he hikes it I would blast right through the gut to kill his run and if he passes the ball he better do it quick or he will be dust. Is this cheap? Yes but the way he is playing is also. In the real NFL when the defense is sure of a run players like Polamolu blast right through as I am telling you to do. This kind of play requires a 4-3 defense with and allin line stunt.
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Hope this helps.