Heelfan, have you tried playing with the Speed Threshold down? I have it set at 35 right now and like it because it actually allows for some separation between WR's and LB's. With the Threshold higher, it seemed like LB's were able to hang stride-for-stride with slot wideouts. With it lower, you can get a couple of steps on a LB the longer the play goes.
Of course, Threshold is a personal preference thing
I'm using MySkill but haven't touched the CPU sliders. I agree that pass rush is much better using MySkill than custom sliders.